Terminated Clinical Trials

If a clinical trial has been terminated, it indicates that recruiting or enrolling participants has halted prematurely and will not resume. Furthermore, participants are no longer examined or treated if researchers have taken this step. Termination of clinical trials often occurs after result tracking has indicated potentially dangerous side effects in patients. These trials are carried out to determine the safety of the medications or procedures in question and any hazard is addressed quickly and completely. Many companies also follow a specific procedure after a clinical trial has been terminated. Particularly for major drug manufacturers, who must maintain a pristine reputation to survive in an extremely competitive industry, transparency and caution are of the utmost importance regarding these trials. In order to maintain the public’s trust, major pharmaceutical companies take extreme care during all scenarios of a clinical trial, particularly during those which have been terminated. This means that if a clinical trial being performed on a marketed product is terminated prematurely for safety reasons, the pharmaceutical company will quickly disclose to medical authorities and the public all medically-important information. Furthermore, these companies will also likely update the status of such a trial on clinicaltrials.gov shortly after the termination as well. Finally, an online summary or report may be published as well, explaining the event. If a clinical trial is terminated due to efficacy reasons, the researchers will also disclose the reasons surrounding such an action, though this process is not as time-sensitive as a trial halted for safety concerns. The summaries of terminated trials provide important information to the public, such as patient disposition, an explanation of why the trial was terminated, and safety or adverse experiences which were noted. References: